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Using contrast patterns between true complexes and random subgraphs in PPI networks to predict unknown protein complexes

Most protein complex detection methods utilize unsupervised techniques to cluster densely connected nodes in a protein-protein interaction (PPI) network, in spite of the fact that many true complexes are not dense subgraphs. Supervised methods have been proposed recently, but they do not answer why...

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Detalles Bibliográficos
Autores principales: Liu, Quanzhong, Song, Jiangning, Li, Jinyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751475/
https://www.ncbi.nlm.nih.gov/pubmed/26868667
http://dx.doi.org/10.1038/srep21223