LPS causes pericyte loss and microvascular dysfunction via disruption of Sirt3/angiopoietins/Tie-2 and HIF-2α/Notch3 pathways

Recent studies reveal a crucial role of pericyte loss in sepsis-associated microvascular dysfunction. Sirtuin 3 (SIRT3) mediates histone protein post-translational modification related to aging and ischemic disease. This study investigated the involvement of SIRT3 in LPS-induced pericyte loss and mi...

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Detalles Bibliográficos
Autores principales: Zeng, Heng, He, Xiaochen, Tuo, Qin-hui, Liao, Duan-fang, Zhang, Guo-qiang, Chen, Jian-xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751495/
https://www.ncbi.nlm.nih.gov/pubmed/26868537
http://dx.doi.org/10.1038/srep20931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751495/
https://www.ncbi.nlm.nih.gov/pubmed/26868537
http://dx.doi.org/10.1038/srep20931

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