Augmenting the logrank test in the design of clinical trials in which non-proportional hazards of the treatment effect may be anticipated

BACKGROUND: Most randomized controlled trials with a time-to-event outcome are designed assuming proportional hazards (PH) of the treatment effect. The sample size calculation is based on a logrank test. However, non-proportional hazards are increasingly common. At analysis, the estimated hazards ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Royston, Patrick, Parmar, Mahesh K.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751641/
https://www.ncbi.nlm.nih.gov/pubmed/26869168
http://dx.doi.org/10.1186/s12874-016-0110-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751641/
https://www.ncbi.nlm.nih.gov/pubmed/26869168
http://dx.doi.org/10.1186/s12874-016-0110-x

Ejemplares similares