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Deriving Heterospecific Self-Assembling Protein–Protein Interactions Using a Computational Interactome Screen
Interactions between naturally occurring proteins are highly specific, with protein-network imbalances associated with numerous diseases. For designed protein–protein interactions (PPIs), required specificity can be notoriously difficult to engineer. To accelerate this process, we have derived pepti...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751974/ https://www.ncbi.nlm.nih.gov/pubmed/26655848 http://dx.doi.org/10.1016/j.jmb.2015.11.022 |