PPARδ repression in Huntington’s disease and its essential role in CNS translate into a potent agonist therapy

Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG-polyglutamine repeat expansion in the huntingtin (htt) gene. We found that peroxisome proliferator-activated receptor delta (PPARδ) interacts with htt and that mutant htt represses PPARδ-mediated transactivation. I...

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Detalles Bibliográficos
Autores principales: Dickey, Audrey S., Pineda, Victor V., Tsunemi, Taiji, Liu, Patrick P., Miranda, Helen C., Gilmore-Hall, Stephen K., Lomas, Nicole, Sampat, Kunal R., Buttgereit, Anne, Torres, Mark-Joseph Manalang, Flores, April L., Arreola, Martin, Arbez, Nicolas, Akimov, Sergey S., Gaasterland, Terry, Lazarowski, Eduardo R., Ross, Christopher A., Yeo, Gene W., Sopher, Bryce L., Magnuson, Gavin K., Pinkerton, Anthony B., Masliah, Eliezer, La Spada, Albert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752002/
https://www.ncbi.nlm.nih.gov/pubmed/26642438
http://dx.doi.org/10.1038/nm.4003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752002/
https://www.ncbi.nlm.nih.gov/pubmed/26642438
http://dx.doi.org/10.1038/nm.4003

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