Cargando…

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial

BACKGROUND: HIV-1 eradication may require reactivation of latent virus along with stimulation of HIV-1-specific immune responses to clear infected cells. Immunization with autologous dendritic cells (DCs) transfected with viral mRNA is a promising strategy for eliciting HIV-1-specific immune respons...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gandhi, Rajesh T., Kwon, Douglas S., Macklin, Eric A., Shopis, Janet R., McLean, Anna P., McBrine, Nicole, Flynn, Theresa, Peter, Lauren, Sbrolla, Amy, Kaufmann, Daniel E., Porichis, Filippos, Walker, Bruce D., Bhardwaj, Nina, Barouch, Dan H., Kavanagh, Daniel G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JAIDS Journal of Acquired Immune Deficiency Syndromes 2016
Materias:	Basic and Translational Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752409/ https://www.ncbi.nlm.nih.gov/pubmed/26379068 http://dx.doi.org/10.1097/QAI.0000000000000852

Ejemplares similares

Stimulation of antiviral cellular immune responses by therapeutic vaccination of HIV-1-infected patients with dendritic cells transfected with gag, tat, rev and nef mRNA
por: Van Gulck, Ellen, et al.
Publicado: (2011)

Analysis of T cell responses to chimpanzee adenovirus vectors encoding HIV gag–pol–nef antigen
por: Herath, S., et al.
Publicado: (2015)

HLA-Associated Immune Escape Pathways in HIV-1 Subtype B Gag, Pol and Nef Proteins
por: Brumme, Zabrina L., et al.
Publicado: (2009)

HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer
por: Malbec, Marine, et al.
Publicado: (2013)

Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic
por: Tongo, Marcel, et al.
Publicado: (2013)

Quantitative Effect of Suboptimal Codon Usage on Translational Efficiency of mRNA Encoding HIV-1 gag in Intact T Cells
por: Ngumbela, Kholiswa C., et al.
Publicado: (2008)

A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein and Adenovirus 35 Gag-RT-Int-Nef Vaccine in Healthy HIV-Uninfected African Adults
por: Omosa-Manyonyi, Gloria, et al.
Publicado: (2015)

The recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono- and multi-clade epidemics: implications for HIV vaccine design
por: Zembe, L, et al.
Publicado: (2012)

P20-18. Diversity of Gag and Nef immunodominant regions in Brazilian HIV-1 B and F1 subtypes
por: Côrtes, FH, et al.
Publicado: (2009)

Predictors of HVTN 503 MRK-AD5 HIV-1 gag/pol/nef Vaccine Induced Immune Responses
por: Hopkins, Kathryn L., et al.
Publicado: (2014)

Effect of ART on poly functional profile of CD8 responses to Gag and Nef antigen in HIV infected Indian individuals
por: Mendiratta, Sanjay, et al.
Publicado: (2014)

HIV-1 Nef: at the crossroads
por: Foster, John L, et al.
Publicado: (2008)

MRKAd5 HIV-1 Gag/Pol/Nef Vaccine-Induced T-Cell Responses Inadequately Predict Distance of Breakthrough HIV-1 Sequences to the Vaccine or Viral Load
por: Janes, Holly, et al.
Publicado: (2012)

Comparison of HIV-1 nef and gag Variations and Host HLA Characteristics as Determinants of Disease Progression among HIV-1 Vertically Infected Kenyan Children
por: Saina, Matilda Chelimo, et al.
Publicado: (2015)

P16-16. Gag and Nef specific T-cell responses in HIV-1 infected long-term non-progressors in Uganda
por: Kyosiimire-Lugemwa, J, et al.
Publicado: (2009)

No Evidence for Selection of HIV-1 with Enhanced Gag-Protease or Nef Function among Breakthrough Infections in the CAPRISA 004 Tenofovir Microbicide Trial
por: Chopera, Denis R., et al.
Publicado: (2013)

The activity of Nef on HIV-1 infectivity
por: Basmaciogullari, Stéphane, et al.
Publicado: (2014)

Gag-Gag Interactions Are Insufficient to Fully Stabilize and Order the Immature HIV Gag Lattice
por: Saha, Ipsita, et al.
Publicado: (2021)

FRET analysis of HIV‐1 Gag and GagPol interactions
por: Takagi, Shimon, et al.
Publicado: (2017)

TNF and HIV-1 Nef: An Intimate Interplay
por: Herbein, Georges
Publicado: (2016)

P16-11. HLA-B57/5801 induces preferential CD27 expression on HIV-Gag but not Nef specific central memory CD8+T cells controlling HIV
por: Xie, J, et al.
Publicado: (2009)

P19-32. HIV-1 vaccine design based on human vaccine trials to improve Gag, Pol, Nef and Env specific immune responses
por: Wild, J, et al.
Publicado: (2009)

Alkylating HIV-1 Nef - a potential way of HIV intervention
por: Jin, Yong-Jiu, et al.
Publicado: (2010)

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities
por: Martínez-Bonet, Marta, et al.
Publicado: (2015)

P16-08. Combined blockade of the PD-1 and IL-10 pathways synergistically enhance HIV-specific CD4 T cell functions
por: Porichis, F, et al.
Publicado: (2009)

Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
por: Mwimanzi, Philip, et al.
Publicado: (2011)

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity
por: Sami Saribas, A, et al.
Publicado: (2017)

Chemotactic activity of HIV-1 Nef for human monocytes
por: Lehmann, MH, et al.
Publicado: (2006)

Understanding the nature of the Nef requirement for HIV-1 infectivity
por: Rosa, Annachiara, et al.
Publicado: (2013)

HIV-1 Nef blocks autophagy in human astrocytes
por: Sardo, Luca, et al.
Publicado: (2015)

Synergy and allostery in ligand binding by HIV-1 Nef
por: Aldehaiman, Abdullah, et al.
Publicado: (2021)

Expression and frameshifting but extremely inefficient proteolytic processing of the HIV-1 gag and pol gene products in stably transfected rodent cell lines
por: Moosmayer, Dieter, et al.
Publicado: (1991)

Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance
por: Korniy, Natalia, et al.
Publicado: (2019)

Effects of reduced gag cleavage efficiency on HIV-1 Gag-Pol package
por: Lin, Yi-Ru, et al.
Publicado: (2022)

PD-1, IL-10, IFN-γ and IL-12 form a network to regulate HIV-1-specific CD4 T Cell and antigen-presenting cell function
por: Porichis, F, et al.
Publicado: (2012)

P08-06 LB. A genome-wide association study of host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the STEP trial
por: Fellay, J, et al.
Publicado: (2009)

HIV-1 Nef Protein Structures Associated with Brain Infection and Dementia Pathogenesis
por: Lamers, Susanna L., et al.
Publicado: (2011)

CTL epitope distribution patterns in the Gag and Nef proteins of HIV-1 from subtype A infected subjects in Kenya: Use of multiple peptide sets increases the detectable breadth of the CTL response
por: Currier, Jeffrey R, et al.
Publicado: (2006)

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo
por: Gorry, Paul R, et al.
Publicado: (2007)

Induction of HIV-specific T-cell responses by gag
por: Van Gulck, Ellen, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_lr0j8lt46dgqgibj28a47bs62f