Effect of Ethanol on the Metabolic Characteristics of HIV-1 Integrase Inhibitor Elvitegravir and Elvitegravir/Cobicistat with CYP3A: An Analysis Using a Newly Developed LC-MS/MS Method

Elvitegravir (EVG), an integrase inhibitor for the treatment HIV infection, is increasingly becoming the part of first-line antiretroviral therapy (ART) regimen. EVG is mainly metabolized through cytochrome P450 (CYP) 3A4. Previously, we have shown that ethanol alters ART-CYP3A4 interactions with pr...

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Detalles Bibliográficos
Autores principales: Midde, Narasimha M., Rahman, Mohammad A., Rathi, Chetan, Li, Junhao, Meibohm, Bernd, Li, Weihua, Kumar, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752462/
https://www.ncbi.nlm.nih.gov/pubmed/26872388
http://dx.doi.org/10.1371/journal.pone.0149225

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752462/
https://www.ncbi.nlm.nih.gov/pubmed/26872388
http://dx.doi.org/10.1371/journal.pone.0149225

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