Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

Highly pathogenic human respiratory coronaviruses cause acute lethal disease characterized by exuberant inflammatory responses and lung damage. However, the factors leading to lung pathology are not well understood. Using mice infected with SARS (severe acute respiratory syndrome)-CoV, we show that...

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Detalles Bibliográficos
Autores principales: Channappanavar, Rudragouda, Fehr, Anthony R., Vijay, Rahul, Mack, Matthias, Zhao, Jincun, Meyerholz, David K., Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752723/
https://www.ncbi.nlm.nih.gov/pubmed/26867177
http://dx.doi.org/10.1016/j.chom.2016.01.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752723/
https://www.ncbi.nlm.nih.gov/pubmed/26867177
http://dx.doi.org/10.1016/j.chom.2016.01.007

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