Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming

The POU domain transcription factor Oct4 plays critical roles in self-renewal and pluripotency of embryonic stem cells (ESCs). Together with Sox2, Klf4 and c-Myc, Oct4 can reprogram any other cell types to pluripotency, in which Oct4 is the only factor that cannot be functionally replaced by other P...

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Detalles Bibliográficos
Autores principales: Jin, Wensong, Wang, Lei, Zhu, Fei, Tan, Weiqi, Lin, Wei, Chen, Dahua, Sun, Qinmiao, Xia, Zongping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753506/
https://www.ncbi.nlm.nih.gov/pubmed/26877091
http://dx.doi.org/10.1038/srep20818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753506/
https://www.ncbi.nlm.nih.gov/pubmed/26877091
http://dx.doi.org/10.1038/srep20818

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