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Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
Dihydrofolate reductase from Escherichia coli (ecDHFR) serves as a model system for investigating the role of protein dynamics in enzyme catalysis. We discuss calculations predicting a network of dynamic motions that is coupled to the chemical step catalyzed by this enzyme. Kinetic studies testing t...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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F1000Research
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754028/ https://www.ncbi.nlm.nih.gov/pubmed/26918149 http://dx.doi.org/10.12688/f1000research.6968.1 |