Lysosomal recruitment of TSC2 is a universal response to cellular stress

mTORC1 promotes cell growth and is therefore inactivated upon unfavourable growth conditions. Signalling pathways downstream of most cellular stresses converge on TSC1/2, which serves as an integration point that inhibits mTORC1. The TSC1/2 complex was shown to translocate to lysosomes to inactivate...

Descripción completa

Detalles Bibliográficos
Autores principales: Demetriades, Constantinos, Plescher, Monika, Teleman, Aurelio A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754342/
https://www.ncbi.nlm.nih.gov/pubmed/26868506
http://dx.doi.org/10.1038/ncomms10662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754342/
https://www.ncbi.nlm.nih.gov/pubmed/26868506
http://dx.doi.org/10.1038/ncomms10662

Ejemplares similares