Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods

Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypot...

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Autores principales: Xu, Zhen, Takizawa, Fumio, Parra, David, Gómez, Daniela, von Gersdorff Jørgensen, Louise, LaPatra, Scott E., Sunyer, J. Oriol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754351/
https://www.ncbi.nlm.nih.gov/pubmed/26869478
http://dx.doi.org/10.1038/ncomms10728
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author Xu, Zhen
Takizawa, Fumio
Parra, David
Gómez, Daniela
von Gersdorff Jørgensen, Louise
LaPatra, Scott E.
Sunyer, J. Oriol
author_facet Xu, Zhen
Takizawa, Fumio
Parra, David
Gómez, Daniela
von Gersdorff Jørgensen, Louise
LaPatra, Scott E.
Sunyer, J. Oriol
author_sort Xu, Zhen
collection PubMed
description Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT(+) B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods.
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spelling pubmed-47543512016-03-04 Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods Xu, Zhen Takizawa, Fumio Parra, David Gómez, Daniela von Gersdorff Jørgensen, Louise LaPatra, Scott E. Sunyer, J. Oriol Nat Commun Article Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT(+) B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods. Nature Publishing Group 2016-02-12 /pmc/articles/PMC4754351/ /pubmed/26869478 http://dx.doi.org/10.1038/ncomms10728 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Xu, Zhen
Takizawa, Fumio
Parra, David
Gómez, Daniela
von Gersdorff Jørgensen, Louise
LaPatra, Scott E.
Sunyer, J. Oriol
Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title_full Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title_fullStr Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title_full_unstemmed Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title_short Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
title_sort mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754351/
https://www.ncbi.nlm.nih.gov/pubmed/26869478
http://dx.doi.org/10.1038/ncomms10728
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