Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypot...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754351/ https://www.ncbi.nlm.nih.gov/pubmed/26869478 http://dx.doi.org/10.1038/ncomms10728 |
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author | Xu, Zhen Takizawa, Fumio Parra, David Gómez, Daniela von Gersdorff Jørgensen, Louise LaPatra, Scott E. Sunyer, J. Oriol |
author_facet | Xu, Zhen Takizawa, Fumio Parra, David Gómez, Daniela von Gersdorff Jørgensen, Louise LaPatra, Scott E. Sunyer, J. Oriol |
author_sort | Xu, Zhen |
collection | PubMed |
description | Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT(+) B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods. |
format | Online Article Text |
id | pubmed-4754351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-47543512016-03-04 Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods Xu, Zhen Takizawa, Fumio Parra, David Gómez, Daniela von Gersdorff Jørgensen, Louise LaPatra, Scott E. Sunyer, J. Oriol Nat Commun Article Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT(+) B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods. Nature Publishing Group 2016-02-12 /pmc/articles/PMC4754351/ /pubmed/26869478 http://dx.doi.org/10.1038/ncomms10728 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Xu, Zhen Takizawa, Fumio Parra, David Gómez, Daniela von Gersdorff Jørgensen, Louise LaPatra, Scott E. Sunyer, J. Oriol Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title | Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title_full | Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title_fullStr | Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title_full_unstemmed | Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title_short | Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
title_sort | mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754351/ https://www.ncbi.nlm.nih.gov/pubmed/26869478 http://dx.doi.org/10.1038/ncomms10728 |
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