CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase

Selective neuronal loss is a hallmark of neurodegenerative diseases, which counter-intuitively are often caused by mutations in widely-expressed genes(1). Charcot-Marie-Tooth (CMT) diseases are the most common hereditary peripheral neuropathies, for which there are no effective therapies(2,3). A sub...

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Detalles Bibliográficos
Autores principales: He, Weiwei, Bai, Ge, Zhou, Huihao, Wei, Na, White, Nicholas M., Lauer, Janelle, Liu, Huaqing, Shi, Yi, Dumitru, Calin Dan, Lettieri, Karen, Shubayev, Veronica, Jordanova, Albena, Guergueltcheva, Velina, Griffin, Patrick R., Burgess, Robert W., Pfaff, Samuel L., Yang, Xiang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754353/
https://www.ncbi.nlm.nih.gov/pubmed/26503042
http://dx.doi.org/10.1038/nature15510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754353/
https://www.ncbi.nlm.nih.gov/pubmed/26503042
http://dx.doi.org/10.1038/nature15510

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