Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening

The primate-specific brain voltage-gated potassium channel isoform Kv11.1-3.1 has been identified as a novel therapeutic target for the treatment of schizophrenia. While this ether-a-go-go related K( + )channel has shown clinical relevance, drug discovery efforts have been hampered due to low and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Calcaterra, Nicholas E., Hoeppner, Daniel J., Wei, Huijun, Jaffe, Andrew E., Maher, Brady J., Barrow, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754628/
https://www.ncbi.nlm.nih.gov/pubmed/26879421
http://dx.doi.org/10.1038/srep19976

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754628/
https://www.ncbi.nlm.nih.gov/pubmed/26879421
http://dx.doi.org/10.1038/srep19976

Ejemplares similares