Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel

TREK-2, a member of two-pore-domain potassium channel family, regulates cellular excitability in response to diverse stimuli. However, how such stimuli control channel function remains unclear. Here, by characterizing the responses of cytosolic proximal C-terminus deletant (ΔpCt) and transmembrane s...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhuo, Ren-Gong, Peng, Peng, Liu, Xiao-Yan, Yan, Hai-Tao, Xu, Jiang-Ping, Zheng, Jian-Quan, Wei, Xiao-Li, Ma, Xiao-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754649/
https://www.ncbi.nlm.nih.gov/pubmed/26879043
http://dx.doi.org/10.1038/srep21248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754649/
https://www.ncbi.nlm.nih.gov/pubmed/26879043
http://dx.doi.org/10.1038/srep21248

Ejemplares similares