Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species

Aggregation of human islet amyloid polypeptide (hIAPP) into fibrils and plaques is associated with pancreatic β-cell loss in type 2 diabetes (T2D). However, due to the rapidness of hIAPP conversion in aqueous phase, exactly which hIAPP species is responsible for the observed toxicity and through wha...

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Detalles Bibliográficos
Autores principales: Pilkington, Emily H., Gurzov, Esteban N., Kakinen, Aleksandr, Litwak, Sara A., Stanley, William J., Davis, Thomas P., Ke, Pu Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754679/
https://www.ncbi.nlm.nih.gov/pubmed/26880502
http://dx.doi.org/10.1038/srep21274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754679/
https://www.ncbi.nlm.nih.gov/pubmed/26880502
http://dx.doi.org/10.1038/srep21274

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