Morpholino-mediated SOD1 reduction ameliorates an amyotrophic lateral sclerosis disease phenotype

Neurotoxicity due to the accumulation of mutant proteins is thought to drive pathogenesis in neurodegenerative diseases. Mutations in superoxide dismutase 1 (SOD1) are linked to familial amyotrophic lateral sclerosis (fALS); these mutations result in progressive motor neuron death through one or mor...

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Detalles Bibliográficos
Autores principales: Nizzardo, M., Simone, C., Rizzo, F., Ulzi, G., Ramirez, A., Rizzuti, M., Bordoni, A., Bucchia, M., Gatti, S., Bresolin, N., Comi, G. P., Corti, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754711/
https://www.ncbi.nlm.nih.gov/pubmed/26878886
http://dx.doi.org/10.1038/srep21301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754711/
https://www.ncbi.nlm.nih.gov/pubmed/26878886
http://dx.doi.org/10.1038/srep21301

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