Rilpivirine analogs potently inhibit drug-resistant HIV-1 mutants

BACKGROUND: Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiretroviral compounds that bind in an allosteric binding pocket in HIV-1 RT, located about 10 Å from the polymerase active site. Binding of an NNRTI causes structural changes that perturb the alignment of the prime...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Steven J., Pauly, Gary T., Akram, Aamir, Melody, Kevin, Rai, Ganesha, Maloney, David J., Ambrose, Zandrea, Thomas, Craig J., Schneider, Joel T., Hughes, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833/
https://www.ncbi.nlm.nih.gov/pubmed/26880034
http://dx.doi.org/10.1186/s12977-016-0244-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754833/
https://www.ncbi.nlm.nih.gov/pubmed/26880034
http://dx.doi.org/10.1186/s12977-016-0244-2

Ejemplares similares