Statistical correlation of nonconservative substitutions of HIV gp41 variable amino acid residues with the R5X4 HIV-1 phenotype

BACKGROUND: The interaction of the envelope glycoprotein of HIV-1 (gp120/gp41) with coreceptor molecules has important implications for specific cellular targeting and pathogenesis. Experimental and theoretical evidences have shown a role for gp41 in coreceptor tropism, although there is no consensu...

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Detalles Bibliográficos
Autores principales: Pacheco-Martínez, Elena, Figueroa-Medina, Evangelina, Villarreal, Carlos, Cocho, Germinal, Medina-Franco, José L., Méndez-Lucio, Oscar, Huerta, Leonor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754869/
https://www.ncbi.nlm.nih.gov/pubmed/26879054
http://dx.doi.org/10.1186/s12985-016-0486-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754869/
https://www.ncbi.nlm.nih.gov/pubmed/26879054
http://dx.doi.org/10.1186/s12985-016-0486-6

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