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Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification
BACKGROUND: c-Met is the receptor tyrosine kinase for hepatocyte growth factor (HGF) encoded by the MET proto-oncogene. Aberrant activation of c-Met resulting from MET amplification and c-Met overexpression is associated with poor clinical outcome in multiple malignancies underscoring the importance...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755020/ https://www.ncbi.nlm.nih.gov/pubmed/26879245 http://dx.doi.org/10.1186/s12885-016-2138-z |