Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification

BACKGROUND: c-Met is the receptor tyrosine kinase for hepatocyte growth factor (HGF) encoded by the MET proto-oncogene. Aberrant activation of c-Met resulting from MET amplification and c-Met overexpression is associated with poor clinical outcome in multiple malignancies underscoring the importance...

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Detalles Bibliográficos
Autores principales: Wang, Jieyi, Goetsch, Liliane, Tucker, Lora, Zhang, Qian, Gonzalez, Alexandra, Vaidya, Kedar S., Oleksijew, Anatol, Boghaert, Erwin, Song, Minghao, Sokolova, Irina, Pestova, Ekaterina, Anderson, Mark, Pappano, William N., Ansell, Peter, Bhathena, Anahita, Naumovski, Louie, Corvaia, Nathalie, Reilly, Edward B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755020/
https://www.ncbi.nlm.nih.gov/pubmed/26879245
http://dx.doi.org/10.1186/s12885-016-2138-z

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