Cargando…

Mangrove dolabrane‐type of diterpenes tagalsins suppresses tumor growth via ROS‐mediated apoptosis and ATM/ATR–Chk1/Chk2‐regulated cell cycle arrest

Natural compounds are an important source for drug development. With an increasing cancer rate worldwide there is an urgent quest for new anti‐cancer drugs. In this study, we show that a group of dolabrane‐type of diterpenes, collectively named tagalsins, isolated from the Chinese mangrove genus Cer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Neumann, Jennifer, Yang, Yi, Köhler, Rebecca, Giaisi, Marco, Witzens‐Harig, Mathias, Liu, Dong, Krammer, Peter H., Lin, Wenhan, Li‐Weber, Min
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Cancer Therapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755134/ https://www.ncbi.nlm.nih.gov/pubmed/26061604 http://dx.doi.org/10.1002/ijc.29629

Ejemplares similares

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy
por: Manic, Gwenola, et al.
Publicado: (2015)

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
por: Di Benedetto, Anna, et al.
Publicado: (2017)

7-Ketocholesterol induces ATM/ATR, Chk1/Chk2, PI3K/Akt signalings, cytotoxicity and IL-8 production in endothelial cells
por: Chang, Mei-Chi, et al.
Publicado: (2016)

Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer
por: Liu, Kang, et al.
Publicado: (2021)

Targeting the ATR-CHK1 Axis in Cancer Therapy
por: Rundle, Stuart, et al.
Publicado: (2017)

ATM/Chk2 and ATR/Chk1 Pathways Respond to DNA Damage Induced by Movento(®) 240SC and Envidor(®) 240SC Keto-Enol Insecticides in the Germarium of Drosophila melanogaster
por: González-Marín, Berenyce, et al.
Publicado: (2023)

Chk1, Chk2, is the amplifier on?
por: Dove, Alan W.
Publicado: (2001)

An ATM–Chk2–INCENP pathway activates the abscission checkpoint
por: Petsalaki, Eleni, et al.
Publicado: (2020)

JAK Inhibition Prevents DNA Damage and Apoptosis in Testicular Ischemia-Reperfusion Injury via Modulation of the ATM/ATR/Chk Pathway
por: Khashab, Farah, et al.
Publicado: (2021)

The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
por: Ma, Hanhui, et al.
Publicado: (2013)

Sensitivity of cells to ATR and CHK1 inhibitors requires hyperactivation of CDK2 rather than endogenous replication stress or ATM dysfunction
por: Ditano, Jennifer P., et al.
Publicado: (2021)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2015)

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
por: Sanjiv, Kumar, et al.
Publicado: (2016)

Clinical Candidates Targeting the ATR–CHK1–WEE1 Axis in Cancer
por: Gorecki, Lukas, et al.
Publicado: (2021)

Natural products targeting the ATR-CHK1 signaling pathway in cancer therapy
por: Ahmed, Salman, et al.
Publicado: (2022)

Correction for The nucleolus stress response is coupled to an ATR-Chk1–mediated G2 arrest
Publicado: (2013)

CTP sensing and Mec1(ATR)-Rad53(CHK1/CHK2) mediate a two-layered response to inhibition of glutamine metabolism
por: Ajazi, Arta, et al.
Publicado: (2022)

Multi-Level Control of the ATM/ATR-CHK1 Axis by the Transcription Factor E4F1 in Triple-Negative Breast Cancer
por: Batnini, Kalil, et al.
Publicado: (2022)

Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice
por: Liu, Huan, et al.
Publicado: (2017)

Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
por: Saini, Priyanka, et al.
Publicado: (2015)

Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors()
por: Job, Albert, et al.
Publicado: (2018)

Nuclear pCHK1 as a potential biomarker of increased sensitivity to ATR inhibition
por: Sundararajan, Vignesh, et al.
Publicado: (2022)

The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing
por: Bruhn, Christopher, et al.
Publicado: (2020)

The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells
por: Tozaki, Yuri, et al.
Publicado: (2023)

Regulation of Chk1
por: Tapia-Alveal, Claudia, et al.
Publicado: (2009)

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation
por: Luo, Daxian, et al.
Publicado: (2023)

Multiple ATR-Chk1 Pathway Proteins Preferentially Associate with Checkpoint-Inducing DNA Substrates
por: Yilmaz, Seçil, et al.
Publicado: (2011)

Critical role of SMG7 in activation of the ATR-CHK1 axis in response to genotoxic stress
por: Ho, Kathleen, et al.
Publicado: (2021)

PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
por: Göder, Anja, et al.
Publicado: (2023)

Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells
por: Sahu, R P, et al.
Publicado: (2009)

Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells
por: Bai, Bingjun, et al.
Publicado: (2020)

Keeping RelApse in Chk: molecular mechanisms of Chk1 inhibitor resistance in lymphoma
por: Black, Elizabeth M., et al.
Publicado: (2022)

ATM/CHK/p53 Pathway Dependent Chemopreventive and Therapeutic Activity on Lung Cancer by Pterostilbene
por: Lee, Hani, et al.
Publicado: (2016)

XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer
por: Wang, Wenjun, et al.
Publicado: (2017)

Licochalcone A Suppresses the Proliferation of Osteosarcoma Cells through Autophagy and ATM-Chk2 Activation
por: Shen, Tai-Shan, et al.
Publicado: (2019)

Duox-generated reactive oxygen species activate ATR/Chk1 to induce G2 arrest in Drosophila tracheoblasts
por: Kizhedathu, Amrutha, et al.
Publicado: (2021)

Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis
por: Smith, Kevin D., et al.
Publicado: (2009)

ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission
por: Mackay, Douglas R., et al.
Publicado: (2015)

Cdc6 contributes to cisplatin-resistance by activation of ATR-Chk1 pathway in bladder cancer cells
por: Chen, Sansan, et al.
Publicado: (2016)

Ciclopirox activates ATR-Chk1 signaling pathway leading to Cdc25A protein degradation
por: Shen, Tao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_t47f9cma8ql21g6lh4gbem509e