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Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice
BACKGROUND: RhoA is an important regulator of platelet responses downstream of Gα(13), yet we still know little about its regulation in platelets. Leukemia‐associated Rho guanine‐nucleotide exchange factor (GEF [LARG]), a RhoA GEF, is highly expressed in platelets and may constitute a major upstream...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755168/ https://www.ncbi.nlm.nih.gov/pubmed/26334261 http://dx.doi.org/10.1111/jth.13129 |