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Leukemia‐associated Rho guanine‐nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice

BACKGROUND: RhoA is an important regulator of platelet responses downstream of Gα(13), yet we still know little about its regulation in platelets. Leukemia‐associated Rho guanine‐nucleotide exchange factor (GEF [LARG]), a RhoA GEF, is highly expressed in platelets and may constitute a major upstream...

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Detalles Bibliográficos
Autores principales:	Williams, C. M., Harper, M. T., Goggs, R., Walsh, T. G., Offermanns, S., Poole, A. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	FIBRINOLYSIS
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755168/ https://www.ncbi.nlm.nih.gov/pubmed/26334261 http://dx.doi.org/10.1111/jth.13129

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