Cargando…

Impaired striatal function in Huntington's disease is due to aberrant p75NTR signaling

Huntington's disease (HD) is a rare genetic neurodegenerative disorder for which there is currently no cure. Early hyperkinetic motor symptoms are consistent with reduced activity of indirect pathway striatal projection neurons (iSPNs) responsible for suppression of unwanted actions. Our recent...

Descripción completa

Detalles Bibliográficos
Autores principales: Plotkin, Joshua L, Surmeier, D James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755240/
https://www.ncbi.nlm.nih.gov/pubmed/26942104
http://dx.doi.org/10.4161/2167549X.2014.968482