Motor neuron degeneration in spinal and Bulbar Muscular Atrophy is a skeletal muscle-driven process: Relevance to therapy development and implications for related motor neuron diseases

Non-cell autonomous degeneration has arisen as an important mechanism in neurodegenerative disorders. Using a novel line of BAC androgen receptor (AR) transgenic mice with a floxed transgene (BAC fxAR121), we uncovered a key role for skeletal muscle in X-linked Spinal and Bulbar Muscular Atrophy (SB...

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Detalles Bibliográficos
Autores principales: Cortes, Constanza J, La Spada, Albert R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Addendum
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755247/
https://www.ncbi.nlm.nih.gov/pubmed/26942099
http://dx.doi.org/10.4161/2167549X.2014.962402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755247/
https://www.ncbi.nlm.nih.gov/pubmed/26942099
http://dx.doi.org/10.4161/2167549X.2014.962402

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