Alk7 Depleted Mice Exhibit Prolonged Cardiac Repolarization and Are Predisposed to Ventricular Arrhythmia

We aimed to investigate the role of activin receptor-like kinase (ALK7) in regulating cardiac electrophysiology. Here, we showed that Alk7(-/-) mice exhibited prolonged QT intervals in telemetry ECG recordings. Furthermore, Langendorff-perfused Alk7(-/-) hearts had significantly longer action potent...

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Detalles Bibliográficos
Autores principales: Ying, Shaozhen, Cao, Hong, Hu, He, Wang, Xin, Tang, Yanhong, Huang, Congxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755580/
https://www.ncbi.nlm.nih.gov/pubmed/26882027
http://dx.doi.org/10.1371/journal.pone.0149205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755580/
https://www.ncbi.nlm.nih.gov/pubmed/26882027
http://dx.doi.org/10.1371/journal.pone.0149205

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