Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis

The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin. Jagn1 mRNA was detected in primary rodent islets and in insulinoma cell lines and the levels were increased in response to ER stress. The functi...

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Detalles Bibliográficos
Autores principales: Nosak, Courtney, Silva, Pamuditha N., Sollazzo, Pietro, Moon, Kyung-Mee, Odisho, Tanya, Foster, Leonard J., Rocheleau, Jonathan V., Volchuk, Allen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755616/
https://www.ncbi.nlm.nih.gov/pubmed/26882284
http://dx.doi.org/10.1371/journal.pone.0149177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755616/
https://www.ncbi.nlm.nih.gov/pubmed/26882284
http://dx.doi.org/10.1371/journal.pone.0149177

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