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Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis
The Jagn1 protein was indentified in a SILAC proteomic screen of proteins that are increased in insulinoma cells expressing a folding-deficient proinsulin. Jagn1 mRNA was detected in primary rodent islets and in insulinoma cell lines and the levels were increased in response to ER stress. The functi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755616/ https://www.ncbi.nlm.nih.gov/pubmed/26882284 http://dx.doi.org/10.1371/journal.pone.0149177 |