Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

BACKGROUND: Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the efficacy and safety of oral pafuramidine in Afric...

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Detalles Bibliográficos
Autores principales: Burri, Christian, Yeramian, Patrick D., Allen, James L., Merolle, Ada, Serge, Kazadi Kyanza, Mpanya, Alain, Lutumba, Pascal, Mesu, Victor Kande Betu Ku, Bilenge, Constantin Miaka Mia, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Thompson, Mark, Munungu, Blaise Fungula, Manuel, Francisco, Josenando, Théophilo, Bernhard, Sonja C., Olson, Carol A., Blum, Johannes, Tidwell, Richard R., Pohlig, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755713/
https://www.ncbi.nlm.nih.gov/pubmed/26881924
http://dx.doi.org/10.1371/journal.pntd.0004362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755713/
https://www.ncbi.nlm.nih.gov/pubmed/26881924
http://dx.doi.org/10.1371/journal.pntd.0004362

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