Cargando…

Efficacy, Safety, and Dose of Pafuramidine, a New Oral Drug for Treatment of First Stage Sleeping Sickness, in a Phase 2a Clinical Study and Phase 2b Randomized Clinical Studies

BACKGROUND: Sleeping sickness (human African trypanosomiasis [HAT]) is caused by protozoan parasites and characterized by a chronic progressive course, which may last up to several years before death. We conducted two Phase 2 studies to determine the efficacy and safety of oral pafuramidine in Afric...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burri, Christian, Yeramian, Patrick D., Allen, James L., Merolle, Ada, Serge, Kazadi Kyanza, Mpanya, Alain, Lutumba, Pascal, Mesu, Victor Kande Betu Ku, Bilenge, Constantin Miaka Mia, Lubaki, Jean-Pierre Fina, Mpoto, Alfred Mpoo, Thompson, Mark, Munungu, Blaise Fungula, Manuel, Francisco, Josenando, Théophilo, Bernhard, Sonja C., Olson, Carol A., Blum, Johannes, Tidwell, Richard R., Pohlig, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755713/ https://www.ncbi.nlm.nih.gov/pubmed/26881924 http://dx.doi.org/10.1371/journal.pntd.0004362

Ejemplares similares

Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial
por: Pohlig, Gabriele, et al.
Publicado: (2016)

Trypanosomiasis Control, Democratic Republic of Congo, 1993–2003
por: Lutumba, Pascal, et al.
Publicado: (2005)

Clinical Study on the Melarsoprol-Related Encephalopathic Syndrome: Risk Factors and HLA Association
por: Seixas, Jorge, et al.
Publicado: (2020)

High Failure Rates of Melarsoprol for Sleeping Sickness, Democratic Republic of Congo
por: Robays, Jo, et al.
Publicado: (2008)

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis
por: Thuita, John K., et al.
Publicado: (2012)

Passive Screening and Diagnosis of Sleeping Sickness with New Tools in Primary Health Services: An Operational Research
por: Mulenga, Philippe, et al.
Publicado: (2019)

Human African Trypanosomiasis Transmission, Kinshasa, Democratic Republic of Congo
por: Simo, Gustave, et al.
Publicado: (2006)

Cost-effectiveness of Algorithms for Confirmation Test of Human African Trypanosomiasis
por: Lutumba, Pascal, et al.
Publicado: (2007)

Whose Elimination? Frontline Workers’ Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences
por: Falisse, Jean-Benoît, et al.
Publicado: (2020)

Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2–3 trial
por: Kande Betu Kumesu, Victor, et al.
Publicado: (2022)

Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk
por: Lumbala, Crispin, et al.
Publicado: (2015)

Should I Get Screened for Sleeping Sickness? A Qualitative Study in Kasai Province, Democratic Republic of Congo
por: Mpanya, Alain, et al.
Publicado: (2012)

Cardiac Alterations in Human African Trypanosomiasis (T.b. gambiense) with Respect to the Disease Stage and Antiparasitic Treatment
por: Blum, Johannes A., et al.
Publicado: (2009)

Storage Stability of Conventional and High Internal Phase Emulsions Stabilized Solely by Chickpea Aquafaba
por: Grossi Bovi Karatay, Graziele, et al.
Publicado: (2022)

Protocol: Developing a framework to improve glycaemic control among patients with type 2 diabetes mellitus in Kinshasa, Democratic Republic of the Congo
por: Fina Lubaki, Jean-Pierre, et al.
Publicado: (2022)

Glycaemic control among type 2 diabetes patients in sub-Saharan Africa from 2012 to 2022: a systematic review and meta-analysis
por: Fina Lubaki, Jean-Pierre, et al.
Publicado: (2022)

Perspectives for glycaemic control in type 2 diabetes in Kinshasa, Democratic Republic of the Congo
por: Lubaki, Jean-Pierre Fina, et al.
Publicado: (2023)

Consensus on potential interventions for improving glycaemic control among patients with type 2 diabetes in Kinshasa, Democratic Republic of the Congo: a Delphi study
por: Lubaki, Jean-Pierre Fina, et al.
Publicado: (2023)

Type 2 diabetes in the Democratic Republic of Congo: an urgent need for a management framework
por: Fina Lubaki, Jean-Pierre, et al.
Publicado: (2023)

Active management of third stage of labour, post–partum haemorrhage and maternal death rate in the Vanga Health Zone, Province of Bandundu, Democratic Republic of the Congo
por: Lubaki, Jean-Pierre Fina, et al.
Publicado: (2010)

Diagnosis and management of a urethral prolapse in a 6-year-old girl: a case report
por: Mayala, Armand Mayala Ma, et al.
Publicado: (2021)

Cost of a new method of active screening for human African trypanosomiasis in the Democratic Republic of the Congo
por: Snijders, Rian, et al.
Publicado: (2020)

Costs and Outcomes of Integrated Human African Trypanosomiasis Surveillance System Using Rapid Diagnostic Tests, Democratic Republic of the Congo
por: Snijders, Rian, et al.
Publicado: (2021)

‘Where are the dead flies!’: perceptions of local communities towards the deployment of Tiny Targets to control tsetse in the Democratic Republic of the Congo
por: Vander Kelen, Catiane, et al.
Publicado: (2022)

Phase diagrams of PEG(1000,1500,2000,4000,6000) + lithium citrate + water ATPSs, and the partitioning of salbutamol at T = 298.15 K
por: Nemati-Kande, Ebrahim, et al.
Publicado: (2023)

Reasons for non-compliance among patients with hypertension at Vanga Hospital, Bandundu Province, Democratic Republic of Congo: A qualitative study
por: Lubaki, Jean-Pierre Fina, et al.
Publicado: (2009)

Community empowerment through participation in a tsetse control project in the Democratic Republic of Congo
por: Vander Kelen, Catiane, et al.
Publicado: (2023)

From Health Advice to Taboo: Community Perspectives on the Treatment of Sleeping Sickness in the Democratic Republic of Congo, a Qualitative Study
por: Mpanya, Alain, et al.
Publicado: (2015)

Human African Trypanosomiasis Diagnosis in First-Line Health Services of Endemic Countries, a Systematic Review
por: Mitashi, Patrick, et al.
Publicado: (2012)

Feasibility of community-based control of tsetse: A pilot project using Tiny Targets in the Democratic Republic of Congo
por: Vander Kelen, Catiane, et al.
Publicado: (2020)

Diagnostic Work-Up of Neurological Syndromes in a Rural African Setting: Knowledge, Attitudes and Practices of Health Care Providers
por: Mpanya, Alain, et al.
Publicado: (2014)

Sensitivity and Specificity of a Prototype Rapid Diagnostic Test for the Detection of Trypanosoma brucei gambiense Infection: A Multi-centric Prospective Study
por: Bisser, Sylvie, et al.
Publicado: (2016)

Prevalence and determinants of psychological insulin resistance among type 2 diabetic patients in Kinshasa, Democratic Republic of Congo
por: Rita, Shomba L., et al.
Publicado: (2019)

Prevalence and determinants of poor glycaemic control amongst patients with diabetes followed at Vanga Evangelical Hospital, Democratic Republic of the Congo
por: Cedrick, Lino Masingo, et al.
Publicado: (2021)

Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial
por: Betu Kumeso, Victor Kande, et al.
Publicado: (2023)

Integration of Human African Trypanosomiasis Control Activities into Primary Health Services in the Democratic Republic of the Congo: A Qualitative Study of Stakeholder Perceptions
por: Mulenga, Philippe, et al.
Publicado: (2019)

Uncomplicated Clinical Malaria Features, the Efficacy of Artesunate-Amodiaquine and Their Relation with Multiplicity of Infection in the Democratic Republic of Congo
por: Muhindo Mavoko, Hypolite, et al.
Publicado: (2016)

Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
por: Lula Ntamba, Yves, et al.
Publicado: (2019)

Fatal Chromobacterium violaceum bacteraemia in rural Bandundu, Democratic Republic of the Congo
por: Bottieau, E., et al.
Publicado: (2014)

Gambiense Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity
por: Lejon, Veerle, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rgvljr75aa2fq660qmq9bbspic