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Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect

Aneuploidy in human eggs is the leading cause of pregnancy loss and Down’s syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely un...

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Detalles Bibliográficos
Autores principales: Zielinska, Agata P, Holubcova, Zuzana, Blayney, Martyn, Elder, Kay, Schuh, Melina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755749/
https://www.ncbi.nlm.nih.gov/pubmed/26670547
http://dx.doi.org/10.7554/eLife.11389