APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

The amyloid precursor protein (APP), whose mutations cause familial Alzheimer’s disease, interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here we mapped this interaction to the NH(2)-terminal region of the APP intracellular domain. A peptide encompassing this bi...

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Detalles Bibliográficos
Autores principales: Fanutza, Tomas, Del Prete, Dolores, Ford, Michael J, Castillo, Pablo E, D’Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755753/
https://www.ncbi.nlm.nih.gov/pubmed/26551565
http://dx.doi.org/10.7554/eLife.09743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755753/
https://www.ncbi.nlm.nih.gov/pubmed/26551565
http://dx.doi.org/10.7554/eLife.09743

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