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APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses
The amyloid precursor protein (APP), whose mutations cause familial Alzheimer’s disease, interacts with the synaptic release machinery, suggesting a role in neurotransmission. Here we mapped this interaction to the NH(2)-terminal region of the APP intracellular domain. A peptide encompassing this bi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755753/ https://www.ncbi.nlm.nih.gov/pubmed/26551565 http://dx.doi.org/10.7554/eLife.09743 |