Protonation of a Glutamate Residue Modulates the Dynamics of the Drug Transporter EmrE

Secondary active transport proteins play a central role in conferring bacterial multidrug resistance. In this work, we investigated the proton-coupled transport mechanism for the Escherichia coli drug efflux pump EmrE using nuclear magnetic resonance (NMR) spectroscopy. Our results show that the glo...

Descripción completa

Detalles Bibliográficos
Autores principales: Gayen, Anindita, Leninger, Maureen, Traaseth, Nathaniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755857/
https://www.ncbi.nlm.nih.gov/pubmed/26751516
http://dx.doi.org/10.1038/nchembio.1999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755857/
https://www.ncbi.nlm.nih.gov/pubmed/26751516
http://dx.doi.org/10.1038/nchembio.1999

Ejemplares similares