Neutrophil P2X(7) receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

Although extracellular ATP is abundant at sites of inflammation, its role in activating inflammasome signalling in neutrophils is not well characterized. In the current study, we demonstrate that human and murine neutrophils express functional cell-surface P2X(7)R, which leads to ATP-induced loss of...

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Detalles Bibliográficos
Autores principales: Karmakar, Mausita, Katsnelson, Michael A., Dubyak, George R., Pearlman, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756306/
https://www.ncbi.nlm.nih.gov/pubmed/26877061
http://dx.doi.org/10.1038/ncomms10555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756306/
https://www.ncbi.nlm.nih.gov/pubmed/26877061
http://dx.doi.org/10.1038/ncomms10555

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