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Long-term safety and stability of angiogenesis induced by balanced single-vector co-expression of PDGF-BB and VEGF(164) in skeletal muscle
Therapeutic angiogenesis by growth factor delivery is an attractive treatment strategy for ischemic diseases, yet clinical efficacy has been elusive. The angiogenic master regulator VEGF-A can induce aberrant angiogenesis if expressed above a threshold level. Since VEGF remains localized in the matr...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756385/ https://www.ncbi.nlm.nih.gov/pubmed/26882992 http://dx.doi.org/10.1038/srep21546 |