Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China

BACKGROUND: Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer is rare in China. The purpose of our study was to investigate the prevalence and risk factors associated with cancer among HIV-infected inpatients in Beijing,...

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Autores principales: Yang, Jun, Su, Shu, Zhao, Hongxin, Wang, Dennis, Wang, Jiali, Zhang, Fujie, Zhao, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756453/
https://www.ncbi.nlm.nih.gov/pubmed/26883427
http://dx.doi.org/10.1186/s12879-016-1416-3
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author Yang, Jun
Su, Shu
Zhao, Hongxin
Wang, Dennis
Wang, Jiali
Zhang, Fujie
Zhao, Yan
author_facet Yang, Jun
Su, Shu
Zhao, Hongxin
Wang, Dennis
Wang, Jiali
Zhang, Fujie
Zhao, Yan
author_sort Yang, Jun
collection PubMed
description BACKGROUND: Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer is rare in China. The purpose of our study was to investigate the prevalence and risk factors associated with cancer among HIV-infected inpatients in Beijing, and to investigate the mortality and risk factors among HIV-infected inpatients with cancer. METHODS: Hospital records from a total of 1946 HIV-infected patients were collected from the Beijing Ditan Hospital. The data, from 2008 to 2013, were collected retrospectively. The cancer diagnoses included AIDS-defining cancers (ADC) and non-AIDS defining cancers (NADC). Logistic regression was used to identify risk factors predicting the concurrence of cancer with HIV. Mortality was examined using Kaplan-Meier estimates and Cox proportional hazards models. RESULTS: 7.7 % (149 cases) of all HIV-infected inpatients had concurrent cancer at their first hospital admission; of those, 33.6 % (50 cases) had ADCs, and 66.4 % (99 cases) had NADCs. The most prevalent NADCs were Hodgkin’s lymphoma, gastrointestinal cancer, liver cancer, and lung cancer. Patients who did not accept antiretroviral therapy (ART) were more likely to suffer from cancer [AOR = 2.07 (1.42–3.01), p = 0.001]. Kaplan-Meier curves indicated that the survival probability of HIV-positive cancer patients was significantly lower than that of HIV-positive cancer-free patients (log-rank test, p < 0.001). For patients diagnosed with cancer, the mortality was also higher among those who did not receive ART [AHR = 2.19 (1.84–2.61), p < 0.001]. CONCLUSION: The prevalence of cancer concurrence among hospitalized HIV-infected patients was 7.7 %. Concurrent cancer also increased mortality among HIV-infected patients. ART was protective against concurrent cancer as well as mortality among HIV-infected cancer patients. These results highlight the importance of promoting cancer screening and early ART initiation among HIV-infected patients.
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spelling pubmed-47564532016-02-18 Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China Yang, Jun Su, Shu Zhao, Hongxin Wang, Dennis Wang, Jiali Zhang, Fujie Zhao, Yan BMC Infect Dis Research Article BACKGROUND: Cancer is responsible for elevated HIV-related morbidity and mortality. Research on HIV-infected patients with concurrent cancer is rare in China. The purpose of our study was to investigate the prevalence and risk factors associated with cancer among HIV-infected inpatients in Beijing, and to investigate the mortality and risk factors among HIV-infected inpatients with cancer. METHODS: Hospital records from a total of 1946 HIV-infected patients were collected from the Beijing Ditan Hospital. The data, from 2008 to 2013, were collected retrospectively. The cancer diagnoses included AIDS-defining cancers (ADC) and non-AIDS defining cancers (NADC). Logistic regression was used to identify risk factors predicting the concurrence of cancer with HIV. Mortality was examined using Kaplan-Meier estimates and Cox proportional hazards models. RESULTS: 7.7 % (149 cases) of all HIV-infected inpatients had concurrent cancer at their first hospital admission; of those, 33.6 % (50 cases) had ADCs, and 66.4 % (99 cases) had NADCs. The most prevalent NADCs were Hodgkin’s lymphoma, gastrointestinal cancer, liver cancer, and lung cancer. Patients who did not accept antiretroviral therapy (ART) were more likely to suffer from cancer [AOR = 2.07 (1.42–3.01), p = 0.001]. Kaplan-Meier curves indicated that the survival probability of HIV-positive cancer patients was significantly lower than that of HIV-positive cancer-free patients (log-rank test, p < 0.001). For patients diagnosed with cancer, the mortality was also higher among those who did not receive ART [AHR = 2.19 (1.84–2.61), p < 0.001]. CONCLUSION: The prevalence of cancer concurrence among hospitalized HIV-infected patients was 7.7 %. Concurrent cancer also increased mortality among HIV-infected patients. ART was protective against concurrent cancer as well as mortality among HIV-infected cancer patients. These results highlight the importance of promoting cancer screening and early ART initiation among HIV-infected patients. BioMed Central 2016-02-16 /pmc/articles/PMC4756453/ /pubmed/26883427 http://dx.doi.org/10.1186/s12879-016-1416-3 Text en © Yang et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yang, Jun
Su, Shu
Zhao, Hongxin
Wang, Dennis
Wang, Jiali
Zhang, Fujie
Zhao, Yan
Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title_full Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title_fullStr Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title_full_unstemmed Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title_short Prevalence and mortality of cancer among HIV-infected inpatients in Beijing, China
title_sort prevalence and mortality of cancer among hiv-infected inpatients in beijing, china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756453/
https://www.ncbi.nlm.nih.gov/pubmed/26883427
http://dx.doi.org/10.1186/s12879-016-1416-3
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