The presence of extra chromosomes leads to genomic instability

Aneuploidy is a hallmark of cancer and underlies genetic disorders characterized by severe developmental defects, yet the molecular mechanisms explaining its effects on cellular physiology remain elusive. Here we show, using a series of human cells with defined aneuploid karyotypes, that gain of a s...

Descripción completa

Detalles Bibliográficos
Autores principales: Passerini, Verena, Ozeri-Galai, Efrat, de Pagter, Mirjam S., Donnelly, Neysan, Schmalbrock, Sarah, Kloosterman, Wigard P., Kerem, Batsheva, Storchová, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756715/
https://www.ncbi.nlm.nih.gov/pubmed/26876972
http://dx.doi.org/10.1038/ncomms10754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756715/
https://www.ncbi.nlm.nih.gov/pubmed/26876972
http://dx.doi.org/10.1038/ncomms10754

Ejemplares similares