Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise in recent clinical trials. Nuclease-driven genome editing provides a method in which to precisely target genetic changes to further en...

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Detalles Bibliográficos
Autores principales: Wang, Jianbin, DeClercq, Joshua J., Hayward, Samuel B., Li, Patrick Wai-Lun, Shivak, David A., Gregory, Philip D., Lee, Gary, Holmes, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756813/
https://www.ncbi.nlm.nih.gov/pubmed/26527725
http://dx.doi.org/10.1093/nar/gkv1121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756813/
https://www.ncbi.nlm.nih.gov/pubmed/26527725
http://dx.doi.org/10.1093/nar/gkv1121

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