Cargando…

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery

The adoptive transfer of engineered T cells for the treatment of cancer, autoimmunity, and infectious disease is a rapidly growing field that has shown great promise in recent clinical trials. Nuclease-driven genome editing provides a method in which to precisely target genetic changes to further en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Jianbin, DeClercq, Joshua J., Hayward, Samuel B., Li, Patrick Wai-Lun, Shivak, David A., Gregory, Philip D., Lee, Gary, Holmes, Michael C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756813/ https://www.ncbi.nlm.nih.gov/pubmed/26527725 http://dx.doi.org/10.1093/nar/gkv1121

Ejemplares similares

Homology-driven genome editing in hematopoietic stem and progenitor cells using zinc finger nuclease mRNA and AAV6 donors
por: Wang, Jianbin, et al.
Publicado: (2015)

Dynamics and competition of CRISPR–Cas9 ribonucleoproteins and AAV donor-mediated NHEJ, MMEJ and HDR editing
por: Fu, Ya-Wen, et al.
Publicado: (2021)

Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases
por: Gupta, Richa, et al.
Publicado: (2017)

Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium
por: Kolb, Anna-Lena, et al.
Publicado: (2017)

The bacterial Mre11–Rad50 homolog SbcCD cleaves opposing strands of DNA by two chemically distinct nuclease reactions
por: Saathoff, Jan-Hinnerk, et al.
Publicado: (2018)

The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81
por: Herrmann, Natalie J., et al.
Publicado: (2015)

Single-strand nicks induce homologous recombination with less toxicity than double-strand breaks using an AAV vector template
por: Metzger, Michael J., et al.
Publicado: (2011)

CRISPR–Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5′ ssDNA exonucleases
por: Radovčić, Marin, et al.
Publicado: (2018)

RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases
por: Guh, Chia-Lun, et al.
Publicado: (2023)

Concerted nicking of donor and chromosomal acceptor DNA promotes homology-directed gene targeting in human cells
por: Gonçalves, Manuel A. F. V., et al.
Publicado: (2012)

A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium
por: Bhullar, Simran, et al.
Publicado: (2018)

Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells
por: Böttcher, Romy, et al.
Publicado: (2014)

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair
por: Hoogenboom, Wouter S, et al.
Publicado: (2019)

Recognition and processing of branched DNA substrates by Slx1–Slx4 nuclease
por: Gaur, Vineet, et al.
Publicado: (2019)

Structural parameters of palindromic repeats determine the specificity of nuclease attack of secondary structures
por: Ait Saada, Anissia, et al.
Publicado: (2021)

The topoisomerase 3 zinc finger domain cooperates with the RMI1 scaffold to promote stable association of the BTR complex to recombination intermediates in the Caenorhabditis elegans germline
por: Dello Stritto, Maria Rosaria, et al.
Publicado: (2022)

Sumoylation of the Rad1 nuclease promotes DNA repair and regulates its DNA association
por: Sarangi, Prabha, et al.
Publicado: (2014)

Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing
por: Carvajal-Maldonado, Denisse, et al.
Publicado: (2019)

Cell cycle-dependent regulation of the nuclease activity of Mus81–Eme1/Mms4
por: Gallo-Fernández, María, et al.
Publicado: (2012)

Recombination hotspots attenuate the coupled ATPase and translocase activities of an AddAB-type helicase–nuclease
por: Gilhooly, Neville S., et al.
Publicado: (2014)

A novel mode of nuclease action is revealed by the bacterial Mre11/Rad50 complex
por: Lim, Chew Theng, et al.
Publicado: (2015)

The RecB helicase-nuclease tether mediates Chi hotspot control of RecBCD enzyme
por: Amundsen, Susan K, et al.
Publicado: (2019)

Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations
por: Poggi, Lucie, et al.
Publicado: (2021)

Processing of eukaryotic Okazaki fragments by redundant nucleases can be uncoupled from ongoing DNA replication in vivo
por: Kahli, Malik, et al.
Publicado: (2019)

Disease-associated DNA2 nuclease–helicase protects cells from lethal chromosome under-replication
por: Falquet, Benoît, et al.
Publicado: (2020)

Cross talk between the nuclease and helicase activities of Dna2: role of an essential iron–sulfur cluster domain
por: Pokharel, Subhash, et al.
Publicado: (2012)

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2
por: Tsabar, Michael, et al.
Publicado: (2015)

The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication
por: Levikova, Maryna, et al.
Publicado: (2015)

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
por: Liao, Shuren, et al.
Publicado: (2016)

Identification of the Xenopus DNA2 protein as a major nuclease for the 5′→3′ strand-specific processing of DNA ends
por: Liao, Shuren, et al.
Publicado: (2008)

Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex
por: Lukaszewicz, Agnieszka, et al.
Publicado: (2013)

A DNA break inducer activates the anticodon nuclease RloC and the adaptive immunity in Acinetobacter baylyi ADP1
por: Klaiman, Daniel, et al.
Publicado: (2014)

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL
por: Al-Behadili, Ali, et al.
Publicado: (2018)

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family
por: Baddock, Hannah T, et al.
Publicado: (2021)

Structure–activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB
por: Warren, Garrett M, et al.
Publicado: (2021)

Diversifying the structure of zinc finger nucleases for high-precision genome editing
por: Paschon, David E., et al.
Publicado: (2019)

hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
por: Richard, Derek J., et al.
Publicado: (2011)

Analysis of repair mechanism choice during homologous recombination
por: Agmon, Neta, et al.
Publicado: (2009)

PALB2 self-interaction controls homologous recombination
por: Buisson, Rémi, et al.
Publicado: (2012)

The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF
por: Jessulat, Matthew, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gkj55fpi22afcu3p7lglddk3vm