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Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate

Regulatory T cells (Tregs) suppress other immune cells and are critical mediators of peripheral tolerance. Therapeutic manipulation of Tregs is subject to numerous clinical investigations including trials for adoptive Treg transfer. Since the number of naturally occurring Tregs (nTregs) is minute, i...

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Detalles Bibliográficos
Autores principales: Schmidt, Angelika, Eriksson, Matilda, Shang, Ming-Mei, Weyd, Heiko, Tegnér, Jesper
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757416/
https://www.ncbi.nlm.nih.gov/pubmed/26886923
http://dx.doi.org/10.1371/journal.pone.0148474