Cargando…

Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate

Regulatory T cells (Tregs) suppress other immune cells and are critical mediators of peripheral tolerance. Therapeutic manipulation of Tregs is subject to numerous clinical investigations including trials for adoptive Treg transfer. Since the number of naturally occurring Tregs (nTregs) is minute, i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmidt, Angelika, Eriksson, Matilda, Shang, Ming-Mei, Weyd, Heiko, Tegnér, Jesper
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757416/ https://www.ncbi.nlm.nih.gov/pubmed/26886923 http://dx.doi.org/10.1371/journal.pone.0148474

Ejemplares similares

Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction of Foxp3 and Il10 genes in developing regulatory T cells
por: Maynard, Craig L., et al.
Publicado: (2009)

Characterization of Protective Human CD4(+)CD25(+) FOXP3(+) Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid
por: Lu, Ling, et al.
Publicado: (2010)

Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3
por: Schmidt, Angelika, et al.
Publicado: (2018)

Correction: Characterization of Protective Human CD4(+)CD25(+) FOXP3(+) Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid
por: Lu, Ling, et al.
Publicado: (2011)

IL-1β Promotes TGF-β1 and IL-2 Dependent Foxp3 Expression in Regulatory T Cells
por: Ganesh, Balaji B., et al.
Publicado: (2011)

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3
por: Mailer, Reiner K. W., et al.
Publicado: (2015)

TGF-β Affects the Differentiation of Human GM-CSF(+) CD4(+) T Cells in an Activation- and Sodium-Dependent Manner
por: Éliás, Szabolcs, et al.
Publicado: (2016)

Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells
por: Éliás, Szabolcs, et al.
Publicado: (2021)

A functionally specialized population of mucosal CD103(+) DCs induces Foxp3(+) regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
por: Coombes, Janine L., et al.
Publicado: (2007)

Retinoic acid-producing DCs and gut-tropic FOXP3(+) regulatory T cells in the induction of oral tolerance
por: Villablanca, Eduardo J.
Publicado: (2013)

Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells
por: Tao, Xiaojuan, et al.
Publicado: (2008)

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells
por: Golovina, Tatiana N., et al.
Publicado: (2011)

FOXP2, retinoic acid, and language: a promising direction
por: Benítez-Burraco, Antonio, et al.
Publicado: (2014)

Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 Downregulation
por: Choi, Garam, et al.
Publicado: (2020)

Foxp3+ Regulatory T-cells and IL-2: The Moirai of T-cell Fates?
por: Gasteiger, Georg, et al.
Publicado: (2012)

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4(+)CD25(+)FOXP3(+) Regulatory T-Cells
por: Monti, Paolo, et al.
Publicado: (2008)

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells
por: Candia, Enzo, et al.
Publicado: (2017)

IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes
por: Apert, Cécile, et al.
Publicado: (2017)

Effect of Size and Loading of Retinoic Acid in Polyvinyl Butyrate Nanoparticles on Amelioration of Colitis
por: Li, Jinting, et al.
Publicado: (2021)

All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells
por: Sun, Xiaohong, et al.
Publicado: (2018)

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus
por: Lu, Ling, et al.
Publicado: (2011)

Butyrate Ameliorates Intestinal Epithelial Barrier Injury Via Enhancing Foxp3+ Regulatory T-Cell Function in Severe Acute Pancreatitis Model
por: Xiao, Shen, et al.
Publicado: (2022)

IL-17A-Producing Foxp3(+) Regulatory T Cells and Human Diseases
por: Jung, Min Kyung, et al.
Publicado: (2017)

In vivo equilibrium of proinflammatory IL-17(+) and regulatory IL-10(+) Foxp3(+) RORγt(+) T cells
por: Lochner, Matthias, et al.
Publicado: (2008)

FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways
por: Devanna, Paolo, et al.
Publicado: (2014)

Treatment of Intestinal Inflammation With Epicutaneous Immunotherapy Requires TGF-β and IL-10 but Not Foxp3(+) Tregs
por: Chen, Xin, et al.
Publicado: (2021)

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
por: Pellegrini, Camilla, et al.
Publicado: (2015)

FOXP3, IL-10, and TGF-β Genes Expression in Children with IgE-Dependent Food Allergy
por: Krogulska, Aneta, et al.
Publicado: (2010)

Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation
por: Freudenberg, Kristin, et al.
Publicado: (2018)

Retinoic Acid Induces Functionally Suppressive Foxp3(+)RORγt(+) T Cells In Vitro
por: Martínez-Blanco, Mónica, et al.
Publicado: (2021)

PSG9 Stimulates Increase in FoxP3(+) Regulatory T-Cells through the TGF-β1 Pathway
por: Jones, Karlie, et al.
Publicado: (2016)

Identification of Retinoic Acid in a High Content Screen for Agents that Overcome the Anti-Myogenic Effect of TGF-Beta-1
por: Krueger, Chateen, et al.
Publicado: (2010)

GATA3-Driven Th2 Responses Inhibit TGF-β1–Induced FOXP3 Expression and the Formation of Regulatory T Cells
por: Mantel, Pierre-Yves, et al.
Publicado: (2007)

Molecular analysis of Annexin expression in cancer
por: Hein, Tobias, et al.
Publicado: (2022)

Phosphoproteomics Reveals Regulatory T Cell-Mediated DEF6 Dephosphorylation That Affects Cytokine Expression in Human Conventional T Cells
por: Joshi, Rubin N., et al.
Publicado: (2017)

An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis
por: Wang, Lifu, et al.
Publicado: (2021)

Transgene IL-6 Enhances DC-Stimulated CTL Responses by Counteracting CD4(+)25(+)Foxp3(+) Regulatory T Cell Suppression via IL-6-Induced Foxp3 Downregulation
por: Bhanumathy, Kalpana Kalyanasundaram, et al.
Publicado: (2014)

CD4(+)FoxP3(+) regulatory T cells confer infectious tolerance in a TGF-β–dependent manner
por: Andersson, John, et al.
Publicado: (2008)

TGF-β1 maintains suppressor function and Foxp3 expression in CD4(+)CD25(+) regulatory T cells
por: Marie, Julien C., et al.
Publicado: (2005)

Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway
por: Grainger, John R., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_l5alfld87hghnejo5lt6reo654