Modular Synthetic Inverters from Zinc Finger Proteins and Small RNAs

Synthetic zinc finger proteins (ZFPs) can be created to target promoter DNA sequences, repressing transcription. The binding of small RNA (sRNA) to ZFP mRNA creates an ultrasensitive response to generate higher effective Hill coefficients. Here we combined three “off the shelf” ZFPs and three sRNAs...

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Detalles Bibliográficos
Autores principales: Hsia, Justin, Holtz, William J., Maharbiz, Michel M., Arcak, Murat, Keasling, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757538/
https://www.ncbi.nlm.nih.gov/pubmed/26886888
http://dx.doi.org/10.1371/journal.pone.0149483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757538/
https://www.ncbi.nlm.nih.gov/pubmed/26886888
http://dx.doi.org/10.1371/journal.pone.0149483

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