Glycosylated Notch and Cancer

Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the a...

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Autores principales: Pakkiriswami, Shanmugasundaram, Couto, Africa, Nagarajan, Usha, Georgiou, Marios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757683/
https://www.ncbi.nlm.nih.gov/pubmed/26925390
http://dx.doi.org/10.3389/fonc.2016.00037
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author Pakkiriswami, Shanmugasundaram
Couto, Africa
Nagarajan, Usha
Georgiou, Marios
author_facet Pakkiriswami, Shanmugasundaram
Couto, Africa
Nagarajan, Usha
Georgiou, Marios
author_sort Pakkiriswami, Shanmugasundaram
collection PubMed
description Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis.
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spelling pubmed-47576832016-02-26 Glycosylated Notch and Cancer Pakkiriswami, Shanmugasundaram Couto, Africa Nagarajan, Usha Georgiou, Marios Front Oncol Oncology Glycosylation is one of the key components influencing several signaling pathways implicated in cell survival and growth. The Notch signaling pathway plays a pivotal role in numerous cell fate specifications during metazoan development. Both Notch and its ligands are repeatedly glycosylated by the addition of sugar moieties, such as O-fucose, O-glucose, or O-xylose, to bring about structural and functional changes. Disruption to glycosylation processes of Notch proteins result in developmental disorders and disease, including cancer. This review summarizes the importance and recent updates on the role of glycosylated Notch proteins in tumorigenesis and tumor metastasis. Frontiers Media S.A. 2016-02-18 /pmc/articles/PMC4757683/ /pubmed/26925390 http://dx.doi.org/10.3389/fonc.2016.00037 Text en Copyright © 2016 Pakkiriswami, Couto, Nagarajan and Georgiou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Pakkiriswami, Shanmugasundaram
Couto, Africa
Nagarajan, Usha
Georgiou, Marios
Glycosylated Notch and Cancer
title Glycosylated Notch and Cancer
title_full Glycosylated Notch and Cancer
title_fullStr Glycosylated Notch and Cancer
title_full_unstemmed Glycosylated Notch and Cancer
title_short Glycosylated Notch and Cancer
title_sort glycosylated notch and cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757683/
https://www.ncbi.nlm.nih.gov/pubmed/26925390
http://dx.doi.org/10.3389/fonc.2016.00037
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