Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

N-Myristoyltransferase (NMT) is a potential drug target in Leishmania parasites. Scaffold-hopping from published inhibitors yielded the serendipitous discovery of a chemotype selective for Leishmania donovani NMT; development led to high affinity inhibitors with excellent ligand efficiency. The bind...

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Detalles Bibliográficos
Autores principales: Rackham, Mark D., Yu, Zhiyong, Brannigan, James A., Heal, William P., Paape, Daniel, Barker, K. Victoria, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757855/
https://www.ncbi.nlm.nih.gov/pubmed/26962429
http://dx.doi.org/10.1039/c5md00241a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757855/
https://www.ncbi.nlm.nih.gov/pubmed/26962429
http://dx.doi.org/10.1039/c5md00241a

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