Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

N-Myristoyltransferase (NMT) represents an attractive drug target in parasitic infections such as malaria due to its genetic essentiality and amenability to inhibition by drug-like small molecules. Scaffold simplification from previously reported inhibitors containing bicyclic cores identified pheny...

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Detalles Bibliográficos
Autores principales: Yu, Zhiyong, Brannigan, James A., Rangachari, Kaveri, Heal, William P., Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757856/
https://www.ncbi.nlm.nih.gov/pubmed/26962430
http://dx.doi.org/10.1039/c5md00242g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757856/
https://www.ncbi.nlm.nih.gov/pubmed/26962430
http://dx.doi.org/10.1039/c5md00242g

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