Subgroup analyses in confirmatory clinical trials: time to be specific about their purposes

BACKGROUND: It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) clinical trials, where conclusions for the overall study population might not hold....

Descripción completa

Detalles Bibliográficos
Autores principales: Tanniou, Julien, van der Tweel, Ingeborg, Teerenstra, Steven, Roes, Kit C. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757983/
https://www.ncbi.nlm.nih.gov/pubmed/26891992
http://dx.doi.org/10.1186/s12874-016-0122-6