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Progression of MRI markers in cerebral small vessel disease: Sample size considerations for clinical trials

Detecting treatment efficacy using cognitive change in trials of cerebral small vessel disease (SVD) has been challenging, making the use of surrogate markers such as magnetic resonance imaging (MRI) attractive. We determined the sensitivity of MRI to change in SVD and used this information to calcu...

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Detalles Bibliográficos
Autores principales: Benjamin, Philip, Zeestraten, Eva, Lambert, Christian, Chis Ster, Irina, Williams, Owen A, Lawrence, Andrew J, Patel, Bhavini, MacKinnon, Andrew D, Barrick, Thomas R, Markus, Hugh S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758545/
https://www.ncbi.nlm.nih.gov/pubmed/26036939
http://dx.doi.org/10.1038/jcbfm.2015.113