Collagen I and the fibroblast: High protein expression requires a new paradigm of post-transcriptional, feedback regulation

BACKGROUND: Scaling protein production seems like a simple perturbation of transcriptional control. However, when embryonic tendon fibroblasts have to produce >50% procollagen and secrete it from the cell 4 times faster than the average protein, this taxes the cellular machinery and requires a fr...

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Detalles Bibliográficos
Autor principal: Schwarz, Richard I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758689/
https://www.ncbi.nlm.nih.gov/pubmed/26900604
http://dx.doi.org/10.1016/j.bbrep.2015.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758689/
https://www.ncbi.nlm.nih.gov/pubmed/26900604
http://dx.doi.org/10.1016/j.bbrep.2015.07.007

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